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  1. Research

    A highly pathogenic simian/human immunodeficiency virus effectively produces infectious virions compared with a less pathogenic virus in cell culture

    The host range of human immunodeficiency virus (HIV) is quite narrow. Therefore, analyzing HIV-1 pathogenesis in vivo has been limited owing to lack of appropriate animal model systems. To overcome this, chime...

    Shoya Iwanami, Yusuke Kakizoe, Satoru Morita, Tomoyuki Miura, Shinji Nakaoka and Shingo Iwami

    Theoretical Biology and Medical Modelling 2017 14:9

    Published on: 21 April 2017

  2. Research

    Establishment of a new initial dose plan for vancomycin using the generalized linear mixed model

    When administering vancomycin hydrochloride (VCM), the initial dose is adjusted to ensure that the steady-state trough value (Css-trough) remains within the effective concentration range. However, the Css-trou...

    Yasuyuki Kourogi, Kenji Ogata, Norito Takamura, Jin Tokunaga, Nao Setoguchi, Mitsuhiro Kai, Emi Tanaka and Susumu Chiyotanda

    Theoretical Biology and Medical Modelling 2017 14:8

    Published on: 8 April 2017

  3. Research

    High resolution hemodynamic profiling of murine arteriovenous fistula using magnetic resonance imaging and computational fluid dynamics

    Arteriovenous fistula (AVF) maturation failure remains a major cause of morbidity and mortality in hemodialysis patients. The two major etiologies of AVF maturation failure are early neointimal hyperplasia dev...

    Daniel Pike, Yan-Ting Shiu, Maheshika Somarathna, Lingling Guo, Tatyana Isayeva, John Totenhagen and Timmy Lee

    Theoretical Biology and Medical Modelling 2017 14:5

    Published on: 20 March 2017

  4. Research

    The role of mobility and health disparities on the transmission dynamics of Tuberculosis

    The transmission dynamics of Tuberculosis (TB) involve complex epidemiological and socio-economical interactions between individuals living in highly distinct regional conditions. The level of exogenous reinfe...

    Victor Moreno, Baltazar Espinoza, Kamal Barley, Marlio Paredes, Derdei Bichara, Anuj Mubayi and Carlos Castillo-Chavez

    Theoretical Biology and Medical Modelling 2017 14:3

    Published on: 28 January 2017

  5. Research

    Thermodynamic considerations in renal separation processes

    Urine production in the kidney is generally thought to be an energy-intensive process requiring large amounts of metabolic activity to power active transport mechanisms. This study uses a thermodynamic analysi...

    Robert H. Louw, David M. Rubin, David Glasser, Robyn F. R. Letts and Diane Hildebrandt

    Theoretical Biology and Medical Modelling 2017 14:2

    Published on: 26 January 2017

  6. Research

    Personalized life expectancy and treatment benefit index of antiretroviral therapy

    The progression of Human Immunodeficiency Virus (HIV) within host includes typical stages and the Antiretroviral Therapy (ART) is shown to be effective in slowing down this progression. There are great challen...

    Yanni Xiao, Xiaodan Sun, Sanyi Tang, Yicang Zhou, Zhihang Peng, Jianhong Wu and Ning Wang

    Theoretical Biology and Medical Modelling 2017 14:1

    Published on: 18 January 2017

  7. Research

    Estimating transmission probability in schools for the 2009 H1N1 influenza pandemic in Italy

    Epidemic models are being extensively used to understand the main pathways of spread of infectious diseases, and thus to assess control methods. Schools are well known to represent hot spots for epidemic sprea...

    Valentina Clamer, Ilaria Dorigatti, Laura Fumanelli, Caterina Rizzo and Andrea Pugliese

    Theoretical Biology and Medical Modelling 2016 13:19

    Published on: 12 October 2016

  8. Research

    Epidemic cycling in a multi-strain SIRS epidemic network model

    One common observation in infectious diseases caused by multi-strain pathogens is that both the incidence of all infections and the relative fraction of infection with each strain oscillate with time (i.e., so...

    Xu-Sheng Zhang

    Theoretical Biology and Medical Modelling 2016 13:14

    Published on: 18 April 2016

  9. Research

    Random walk of passive tracers among randomly moving obstacles

    This study is mainly motivated by the need of understanding how the diffusion behavior of a biomolecule (or even of a larger object) is affected by other moving macromolecules, organelles, and so on, inside a ...

    Matteo Gori, Irene Donato, Elena Floriani, Ilaria Nardecchia and Marco Pettini

    Theoretical Biology and Medical Modelling 2016 13:13

    Published on: 14 April 2016

  10. Research

    Assessing potential countermeasures against the dengue epidemic in non-tropical urban cities

    Dengue is a common mosquito-borne viral disease epidemic especially in tropical and sub-tropical regions where water sanitation is not substantially controlled. However, dengue epidemics sometimes occur in non...

    Hiroki Masui, Itsuki Kakitani, Shumpei Ujiyama, Kazuyoshi Hashidate, Masataka Shiono and Kazue Kudo

    Theoretical Biology and Medical Modelling 2016 13:12

    Published on: 12 April 2016

  11. Review

    The organelle of differentiation in embryos: the cell state splitter

    The cell state splitter is a membraneless organelle at the apical end of each epithelial cell in a developing embryo. It consists of a microfilament ring and an intermediate filament ring subtending a microtub...

    Natalie K. Gordon and Richard Gordon

    Theoretical Biology and Medical Modelling 2016 13:11

    Published on: 10 March 2016

  12. Research

    Modeling glucose and free fatty acid kinetics in glucose and meal tolerance test

    Quantitative evaluation of insulin regulation on plasma glucose and free fatty acid (FFA) in response to external glucose challenge is clinically important to assess the development of insulin resistance (Worl...

    Yanjun Li, Carson C. Chow, Amber B. Courville, Anne E. Sumner and Vipul Periwal

    Theoretical Biology and Medical Modelling 2016 13:8

    Published on: 2 March 2016

  13. Review

    Toward precision medicine of breast cancer

    In this review, we report on breast cancer’s molecular features and on how high throughput technologies are helping in understanding the dynamics of tumorigenesis and cancer progression with the aim of develop...

    Nicolas Carels, Lizânia Borges Spinassé, Tatiana Martins Tilli and Jack Adam Tuszynski

    Theoretical Biology and Medical Modelling 2016 13:7

    Published on: 29 February 2016

  14. Research

    A mathematical model of tumor growth and its response to single irradiation

    Mathematical modeling of biological processes is widely used to enhance quantitative understanding of bio-medical phenomena. This quantitative knowledge can be applied in both clinical and experimental setting...

    Yoichi Watanabe, Erik L. Dahlman, Kevin Z. Leder and Susanta K. Hui

    Theoretical Biology and Medical Modelling 2016 13:6

    Published on: 27 February 2016

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