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Archived Comments for: A statistical model for the identification of genes governing the incidence of cancer with age

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  1. Bedside Diagnosing Oncological Terrain and Inherited Oncological Real Risk in quantitative way.

    Sergio Stagnaro, Quantum Biophysical Semeiotics Research Laboratory

    19 July 2008

    Editors,

    I certainly find the paper by Kiranmoy Das and Rongling Wu fascinating, but really too technical to be utilized at the bedside by general practitioners. My 52-year long, well established clinical experience allows me to state that if we either ignore or overlook the reality of the Oncological Terrain (http://www.semeioticabiofisica.it) as well as the inherited ‘real risk’ of cancer, considered quantitatively, we cannot prevent or diagnose cancer promptly in its initial stage, i.e. Inherited Oncological Real Risk in a biological system [1-4]. In fact, both environmental risk factors and aging, which has been suggested as a risk factor for cancer, ‘could’ influence some biological functions in humans and/or bring about different disorders, such as cancers, exclusively in relation to the presence and intensity of CAEMH in a well-defined biological system. For instance, in spite of aging, NOT all aged individuals are affected by malignancy. As a consequence, we have to consider the importance of ‘genetic predispositions’, i.e. Oncological Terrain as well as Inherited Oncological Risk, located in biological system(s), in regard to the onset of many disorders including breast cancer. In conclusion, we need initially (i.e. starting any screening or research whatever) to investigate the presence and intensity of CAEMH in the ‘tested’ population, i.e. in ‘every’ ‘single’ patient, and quickly thereafter to assess the presence and intensity of the CAEMH-dependent ‘Oncological Terrain’ and the precise location of the congenital ‘real risk’ of cancer. Both always develop on the basis of the above-mentioned congenital mitochondrial cytopathology. In fact, without this alteration in the psycho-neuro-endocrine-immunological system, oncogenesis is not possible. This allows me to state that my 52-year-long clinical experience with Biophysical Semeiotics, Single Patient Based Medicine theory is based on [6]. Finally, these pathological conditions are characterized by microcirculatory remodelling, in which newborn-pathological, type I, ‘typical’ oncological subtype Endoarteriolar Blocking Devices play a key role [1-5, 14, 15].

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    3. Stagnaro S: Mitochondrial Bed-Side Evaluation: a new Way in the War against Cancer (21 December 2005). Cancer Cell International http://www.cancerci.com/content/5/1/34/comments#218502

    4. Stagnaro S, Stagnaro-Neri M: La Melatonina nella Terapia del Terreno Oncologico e del "Reale Rischio" Oncologico. Roma: Travel Factory; 2004. http://www.travelfactory.it/semeiotica_biofisica_2.htm

    5. Stagnaro-Neri M, Stagnaro S: Cancro della mammella: prevenzione primaria e diagnosi precoce con la percussione ascoltata. Gazz Med It Arch Sc Med 1993, 152:447.

    6. Stagnaro S, Stagnaro-Neri M: Single Patient Based Medicine.La Medicina Basata sul Singolo Paziente: Nuove Indicazioni della Melatonina. Roma: Travel Factory; 2005. http://www.travelfactory.it/libro_singlepatientbased.htm

    7. Stagnaro S: Clinical tool reliable in bedside early recognizing pancreas tumour, both benign and malignant. World J Surg Oncol 2005, 3:62 doi:10.1186/1477-7819-3-62.

    8. Stagnaro S: Bed-Side Evaluating Breast Cancer Real Risk. World J Surg Oncol 2005, 3:67 doi:10.1186/1477-7819-3-67. 2005 2005

    9. Stagnaro S: Mitochondrial Bed-Side Evaluation: a new Way in the War against Cancer (21 December 2005). Cancer Cell Internat http://www.cancerci.com/content/5/1/34/comments#218502 2005

    10. Stagnaro S: Cancer Risk Factors and Oncological Terrain. 2006. http://www.wjso.com/content/4/1/74/comments#247528 2006

    11. Stagnaro S: Without Oncological Terrain oncogenesis is not possible. CMAJ. 23 March 2007 http://www.cmaj.ca/cgi/eletters/176/5/646

    12. Stagnaro S: GPs, Biophysical Semeiotics, and bedside cancer diagnosis. 08 July 2007, International Seminar of Surgical Oncology, http://www.issoonline.com/content/4/1/11/comments#281539 , 2007

    13. Stagnaro S: Bedside Evaluation Tobacco's actions on Biological Systems. The Lancet, October 13, 2007, http://www.thelancet.com/journals/lancet/article/

    PIIS0140673607614822/comments?action=view&totalComments=2#1286 2007

    14. Stagnaro S: Oncological Terrain and Inherited Oncological Real Risk: New Way in Malignancy Primary Prevention and early Diagnosis. Internat Sem Surg Oncol, 2007. http://www.issoonline.com/content/4/1/25/comments#290565

    15. Stagnaro S: Bedside Biophysical-Semeiotic Diagnosis of Breast Cancer, since initial Stage. Internat Sem Surg Oncol, 2007, http://www.issoonline.com/content/4/1/21/comments

    Competing interests

    None declared

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