Archived Comments for:
Site-specific dose-response relationships for cancer induction from the combined Japanese A-bomb and Hodgkin cohorts for doses relevant to radiotherapy
Uwe Schneider, University of Zürich and Hirslanden Medical Center
23 March 2012
Dear Reader,
Upon the publication of the manuscript titled ¿Site-specific dose-response relationships for cancer induction from the combined Japanese A-bomb and Hodgkin cohorts for doses relevant to radiotherapy,¿ it was found that EAR for Rectum from the Dores data was obtained (for agex=30 and agea=70) by using the temporal patterns of ¿all solid cancers¿ (parameters¿ game = -0.024 and gamaa = 2.38). However, it would be more realistic to use the temporal patterns for ¿Colon¿ (parameters¿ game = -0.056 and gamaa = 6.9). A re-calculation of EAR for ¿rectum¿ resulted in 12.5 instead of 1.53. As a consequence the EAR model fitted the ¿rectum¿ data with the following results:
- Linear model: not converging
- Full model: alpha=0.033, R=0.56, CV=2.4E-5
- Bell shape: alpha=0.031, R=0, CV=1.9E-3
- Full recovery: alpha=0.065, R=1, CV=7.5E-4
We are sorry that this error was not observed at an earlier stage.
Best regards,
Uwe Schneider
Theoretical Biology and Medical Modelling
Fit parameters for RECTUM
23 March 2012
Dear Reader,
Upon the publication of the manuscript titled ¿Site-specific dose-response relationships for cancer induction from the combined Japanese A-bomb and Hodgkin cohorts for doses relevant to radiotherapy,¿ it was found that EAR for Rectum from the Dores data was obtained (for agex=30 and agea=70) by using the temporal patterns of ¿all solid cancers¿ (parameters¿ game = -0.024 and gamaa = 2.38). However, it would be more realistic to use the temporal patterns for ¿Colon¿ (parameters¿ game = -0.056 and gamaa = 6.9). A re-calculation of EAR for ¿rectum¿ resulted in 12.5 instead of 1.53. As a consequence the EAR model fitted the ¿rectum¿ data with the following results:
- Linear model: not converging
- Full model: alpha=0.033, R=0.56, CV=2.4E-5
- Bell shape: alpha=0.031, R=0, CV=1.9E-3
- Full recovery: alpha=0.065, R=1, CV=7.5E-4
We are sorry that this error was not observed at an earlier stage.
Best regards,
Uwe Schneider
Competing interests
None declared