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Table 2 Odds ratios for comparison using Method 1. Odds ratios for preference of system with suppression using conditional logistic regression (Method 1). The data consisted of 840 groups of 5 cases each (reference and four alternatives) sampled as described. Values shown give the odds that the reference system is preferred over the alternative. Values marked with asterisks are significant at the α = 0.05 level. Kinetic orders and rate constants were sampled with σ = 0.1. Cells marked with an odds ratio of 1 or = indicate cases that were fixed by equivalence.

From: Improved methods for the mathematically controlled comparison of biochemical systems

Functional Performance Objective

Independent Alternative

Internally Equivalent

Partially Equivalent

Fully Equivalent

Irvine and Savageau

Minimize Basal Level of Systemic Antigen

0.76

0.94

1

1

=

Minimize Basal Level of Effector Lymphocytes

0.85

1.1

1

1

=

Minimize Antigenic Gain

0.34*

0.39*

0.36*

1

=

Minimize Effector Gain

1.4*

1.5*

1.8*

1

=

Minimize Dynamic Levels of Antigen

32*

28*

34*

11*

+

Minimize Dynamic Levels of Effector

2.3*

1.9*

2.4*

0.97

+

Minimize Sensitivity to Parameter Variation

11*

12*

13*

5.5*

+