Figure 2

Model of Sandfly fever virus Gc based on predicted structure of a Sindbis virus E1 fusion intermediate. Panel A: A structural intermediate of SFV E1 as determined by Gibbons et al. [33] was projected to SIN E1. Panel B: A model fitting SAN GC to the predicted structure of SIN E1. Structures predicted to be similar are color-coded the same way in SIN E1 and SAN Gc. Grey lines: dicysteine linkages. Black stick figures: N-glycosylation sites (sites with central proline are often not used). Regions with significant Wimley-White interfacial hdrophobicity scale scores were predicted with MpeX (black).