Figure 14

Panel A shows the results of an experiment of Stojilkovic et al.[19] in which rat pituitary cells were exposed to two 30 minute pulses of 100 nM GnRH at one hour intervals. Panel B shows the response of the present model to the same pulses. If, how-ever, the rate of recovery of the calcium channels in the outer membrane is increased from v₂ = 0.002 min^-1 to v₂ = 0.02 min^-1 and the rate internalization of receptors is decreased from k₁₁ = 0.08/n nM^-1·min^-1 to k₁₁ = 0.04/n nM^-1·min^-1, then the present model gives responses (Panel C) similar to the exerperimental results in Panel A. The ordinate units for Panels B and C are ng.