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Table 2 Constants

From: A mathematical model for LH release in response to continuous and pulsatile exposure of gonadotrophs to GnRH

R0 Total receptor concentration (nM)
GQ0 Total Gq/11protein concentration (nM)
ERUL Resting Ca2+ concentration in ER (normally 40 μ M)
CAE External Ca2+ concentration (normally 1000 μ M)
α = 2 nM-1, see equation (17)
β = 4 min-1, see equation (17)
v 1 = 0.02 min-1, see equation (12)
v 2 = 0.002 min-1, see equation (12)
r 0 = 0.6, fraction internalized receptors returned
P0 = 8.3 × 10-6 nM·min-1, basal rate of receptor synthesis
γ = 8.3 × 10-4 min-1, basal rate of receptor degradation
k 1 = 2.5 nM-1·min-1
k -1 = 5 min-1
k 2 = 2500 nM-1·min-1
k -2 = 5 min-1
k 3 = 4000 nM-1·min-1
k -3 = 200 min-1
k 5 = 2 × 107 min-1
k -5 = 10 min-1
k 6 = 1 nM-1·min-1
k 66 = 10 nM-1·min-1
k 666 = 0
k -6 = 5 min-1
k 7 = 2.2 μ M·min-1
k 8 = 0.4 nM-1·min-1
k 88 = 0
k 888 = 0
k 9 = 0.0002 min-1
k 10 = 5 ng·min-1
k 11 = 0.0008 nM-1·min-1
k 33 = 2.7 min-1