Table 2 Constants
R0 | Total receptor concentration (nM) |
|---|---|
GQ0 | Total Gq/11protein concentration (nM) |
ERUL | Resting Ca2+ concentration in ER (normally 40 μ M) |
CAE | External Ca2+ concentration (normally 1000 μ M) |
α | = 2 nM-1, see equation (17) |
β | = 4 min-1, see equation (17) |
v 1 | = 0.02 min-1, see equation (12) |
v 2 | = 0.002 min-1, see equation (12) |
r 0 | = 0.6, fraction internalized receptors returned |
P0 | = 8.3 × 10-6 nM·min-1, basal rate of receptor synthesis |
γ | = 8.3 × 10-4 min-1, basal rate of receptor degradation |
k 1 | = 2.5 nM-1·min-1 |
k -1 | = 5 min-1 |
k 2 | = 2500 nM-1·min-1 |
k -2 | = 5 min-1 |
k 3 | = 4000 nM-1·min-1 |
k -3 | = 200 min-1 |
k 5 | = 2 × 107 min-1 |
k -5 | = 10 min-1 |
k 6 | = 1 nM-1·min-1 |
k 66 | = 10 nM-1·min-1 |
k 666 | = 0 |
k -6 | = 5 min-1 |
k 7 | = 2.2 μ M·min-1 |
k 8 | = 0.4 nM-1·min-1 |
k 88 | = 0 |
k 888 | = 0 |
k 9 | = 0.0002 min-1 |
k 10 | = 5 ng·min-1 |
k 11 | = 0.0008 nM-1·min-1 |
k 33 | = 2.7 min-1 |