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Table 2 Performance of parameter estimation for the time activity model

From: Stochastic time‐concentration activity models for cytotoxicity in 3D brain cell cultures

  B( p) ×10−3 B( w) ×10−3 Coverage probability
ModelA(t) LS ML LS ML LS ML
‘Fast low stress’ .057 .053 .062 .057 .97 [.96,.98] .97 [.96,.98]
‘Fast high stress’ .032 .029 .076 .069 .61 [.58,.64] .97 [.95,.97]
‘Normal low stress’ .009 −.014 .001 −.017 .96 [.95,.97] .96 [.94,.97]
‘Normal high stress’ −.013 −.016 −26.8 −29.7 .95 [.93,.96] .96 [.95,.97]
‘Slow low stress’ 3.2 −.138 5.4 ‐.303 .91 [.89,.93] .94 [.92,.95]
‘Slow high stress’ .090 .006 4.0 −1.7 .92 [.90,.93] .90 [.88,.92]
  1. Bias B of least squares (LS) and maximum likelihood (ML) estimators and coverage probability with a 95% confidence interval of joint estimates for the time activity model determined from 1000 simulations and fits of the scenarios each.