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Table 2 Performance of parameter estimation for the time activity model

From: Stochastic time‐concentration activity models for cytotoxicity in 3D brain cell cultures

 

B( p) ×10−3

B( w) ×10−3

Coverage probability

ModelA(t)

LS

ML

LS

ML

LS

ML

‘Fast low stress’

.057

.053

.062

.057

.97 [.96,.98]

.97 [.96,.98]

‘Fast high stress’

.032

.029

.076

.069

.61 [.58,.64]

.97 [.95,.97]

‘Normal low stress’

.009

−.014

.001

−.017

.96 [.95,.97]

.96 [.94,.97]

‘Normal high stress’

−.013

−.016

−26.8

−29.7

.95 [.93,.96]

.96 [.95,.97]

‘Slow low stress’

3.2

−.138

5.4

‐.303

.91 [.89,.93]

.94 [.92,.95]

‘Slow high stress’

.090

.006

4.0

−1.7

.92 [.90,.93]

.90 [.88,.92]

  1. Bias B of least squares (LS) and maximum likelihood (ML) estimators and coverage probability with a 95% confidence interval of joint estimates for the time activity model determined from 1000 simulations and fits of the scenarios each.
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Theoretical Biology and Medical Modelling

ISSN: 1742-4682