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Table 8 Mutants designed by the third protocol (enhancing interactions)

From: Is it possible to stabilize a thermophilic protein further using sequences and structures of mesophilic proteins: a theoretical case study concerning DgAS

Mutants ΔΔGf ΔLSE Stabilizing forces
A96V −0.92 −0.0016646 VDW
A285R −1.38 0.0016377 VDW, Electrostatics
A287K −0.97 0.0011746 VDW, Electrostatics
S355L −2.64 0.0000178 VDW, hydrophobic
A378S −0.92 0.0015674 Electrostatics
N413D −3.28 0.0003137 Dipole
A415E −2.16 −0.0004484 VDW, Electrostatics
V444Q −0.91 −0.0000552 Electrostatics
D499L −3.00 −0.0019341 VDW, hydrophobic