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Figure 4 | Theoretical Biology and Medical Modelling

Figure 4

From: Mathematical models for the Notch and Wnt signaling pathways and the crosstalk between them during somitogenesis

Figure 4

Simulation results of the Wnt signaling model. (A) The oscillating expressions of Wnt target genes under conditions of a constant extracellular signal. (B) The expression patterns of Wnt target genes after the extracellular Wnt signals were removed at time point 120 minutes. (C) The expression patterns of the Wnt target genes after the extracellular Wnt signals were doubled. (D) The synchronous expressions of Wnt target genes with the downstream Wnt signals and the synchronously delayed expressions between the downstream and upstream Wnt signals. (E) The changes of concentration of active Dsh and the β-catenin- Lef1 complex and the expression patterns of the Wnt target genes after the extracellular signals were knocked out at time point 120 minutes. (F) The expression patterns of the Dll1 gene after the Axin2 gene was knocked out at time point 120 minutes. (G) The phase relationships between active Dsh, the GSK3-Axin2complex, the β-catenin-Lef1 complex and Axin2. (H) The changes of concentration of Axin2, active Dsh, the GSK3-Axin2 complex and the β-catenin-Lef1 complex after the Axin2 gene was knocked out at time point 120 minutes.

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Theoretical Biology and Medical Modelling

ISSN: 1742-4682