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Figure 6 | Theoretical Biology and Medical Modelling

Figure 6

From: Mathematical models for the Notch and Wnt signaling pathways and the crosstalk between them during somitogenesis

Figure 6

Simulation results of the combined model under conditions of normal extracellular signals and knocking out components of the Notch pathway. (A) The oscillating expressions of Notch and Wnt target genes under conditions of a constant extracellular Wnt signal. (B) The expression patterns of the Notch and Wnt target genes after the Notch gene was knocked out at time point 120 minutes. (C) The expression patterns of the Hes7 gene and the Wnt target genes after Lfng was knocked out at time point 120 minutes. (D) The expression patterns of the Lfng gene and the Wnt target genes after the Hes7 gene was knocked out at time point 120 minutes.

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