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Figure 7 | Theoretical Biology and Medical Modelling

Figure 7

From: Mathematical models for the Notch and Wnt signaling pathways and the crosstalk between them during somitogenesis

Figure 7

Simulation results of the combined model under conditions of knocking out components of the Wnt pathway and the Nkd1 gene. (A) The changes in gene-expression oscillation periods of the Wnt and Notch pathways after Wnt signals were reduced. (B) The changes in gene-expression oscillation periods of the Wnt and Notch pathways after Wnt signals were increased 10-fold. (C) The expression patterns of the target genes of the Wnt and Notch pathways after Wnt signals were knocked out at time point 200 minutes. (D) The expression patterns of the target genes of the Wnt and Notch pathways after the Axin2 gene was overexpressed at time point 120 minutes. (E) The expression patterns of the Nkd1 gene after Wnt signals were knocked out at time point 240 minutes. (F) The expression patterns of the Nkd1 gene after the Dll1 gene was knocked out at time point 240 minutes. (G) The expression patterns of the Nkd1 gene after the Hes7 gene was knocked out at time point 120 minutes. (H) The expression patterns of the target genes of the Wnt and Notch pathways after Nkd1 was knocked out at time point 120 minutes.

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