Figure 2

Morphological differences in the drug binding pockets of β-tubulin isotype. Visualization of the morphological differences in the binding pockets of β-tubulin isotypes for five selected drugs: (A) laulimalide, (B) peloruside A, (C) paclitaxel, (D) colchicine, and (E) vinblastine. α-Tubulin is shown in green, β-tubulin is shown in blue, the drug is shown in red, the drug binding pocket is shown in grey, and residue differences are shown in yellow. The paclitaxel complex is based on PDB:1JFF, the colchicine complex is based on PDB:1SA0, and the vinblastine complex is based on PDB:1Z2B.