Determination of the optimal tubulin isotype target as a method for the development of individualized cancer chemotherapy

Table 2 Residue changes between β-tubulin isotypes in the binding site for peloruside A and laulimalide

Isotype	Residue changes in the peloruside/laulimalide binding site
βIIa	C200S	V292M	A295S
βIIb		V292M	A295S
βIII		V292M
βIVa		V292M
βIVb		V292M
βV		V292M	K296R
βVI		V292M	K296R	M298T
Isotype	Residue changes in the peloruside/laulimalide binding site
βIII					N331A	V332I
βIVa					N331S
βV					N331A	V332I
βVI	P304L	H306R	M329L		N331S
Isotype	Residue changes in the peloruside/laulimalide binding site
βIII	N334S
βIVa	N334S
βV	N334S
βVI	N334T	K335R	Y339C

Residue changes between β-tubulin isotypes with respect to the interactions with two novel spindle poisons, peloruside A and laulimalide, divided into three distinct regions that contribute to the interactions between the protein and the ligands.

ISSN: 1742-4682