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Table 3 Binding energy differences for peloruside A and laulimalide as a function of the β-tubulin isotypes

From: Determination of the optimal tubulin isotype target as a method for the development of individualized cancer chemotherapy

 

βI

βIIa

βIIb

βIII

βIVa

βIVb

βV

βVI

PELA

-22.6

-20.3

-10.6

-7.9

-18.2

-2.1

-22.0

0

LAU

0

0

-30.0

0

0

-21.9

-34.9

0

  1. Binding energy differences in (kcal/mol) for peloruside A (PELA) and laulimalide (LAU) as a function of the β-tubulin isotypes. These values are based on molecular dynamics calculations [19].
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Theoretical Biology and Medical Modelling

ISSN: 1742-4682