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Table 3 Binding energy differences for peloruside A and laulimalide as a function of the β-tubulin isotypes

From: Determination of the optimal tubulin isotype target as a method for the development of individualized cancer chemotherapy

  βI βIIa βIIb βIII βIVa βIVb βV βVI
PELA -22.6 -20.3 -10.6 -7.9 -18.2 -2.1 -22.0 0
LAU 0 0 -30.0 0 0 -21.9 -34.9 0
  1. Binding energy differences in (kcal/mol) for peloruside A (PELA) and laulimalide (LAU) as a function of the β-tubulin isotypes. These values are based on molecular dynamics calculations [19].