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Table 4 Estimates for the parameters governing the transmission dynamics of influenza A (H1N1-2009) in a primary school in Madagascar, 2009

From: Effectiveness of antiviral prophylaxis coupled with contact tracing in reducing the transmission of the influenza A (H1N1-2009): a systematic review

Offspring distribution

Depletion of susceptibles

Reproduction number (95% CI ‡)

% Reduction in transmissibility by treatment (95% CI ‡)

% Reduction in transmissibility by contact tracing and chemoprophylaxis (95% CI ‡)

% Reduction in transmissibility by school closure (95% CI ‡)

AIC §

Poisson

Yes

4.8 (1.8, 9.6)

14.1 (0, 72.1)

94.3 (87.6, 97.7)

31.6 (0, 76.8)

37.9

Poisson

No

6.0 (2.2,12.2)

4.4 (0, 68.2)

93.3 (85.6, 97.3)

10.0 (0, 69.5)

35.0

Geometric

Yes

6.6 (1.5, NC)

26.1 (0, NC)

94.1 (71.8, 98.7)

40.6 (0, NC)

39.7

Geometric

No

7.4 (1.6, NC)

12.8 (NC, NC)

92.8 (66.7, 98.4)

15.1 (0, NC)

39.1

Negative binomial

Yes

6.6 (2.2, 16.4)

27.7 (0, 85.5)

95.4 (87.7, 98.4)

48.0 (0, 84.8)

37.6

Negative binomial

No

7.2 (2.5, 17.0)

13.1 (0, 78.4)

94.0 (85.6, 97.8)

22.6 (0, 76.2)

36.1

  1. ‡CI, confidence interval (derived from the profile likelihood); §AIC, Akaike’s information criterion; NC, not calculable; Dispersion parameter estimates for negative binomial distribution are 7.6 and 13.0 for those with and without accounting for depletion of susceptibles.