Boolean network-based model of the Bcl-2 family mediated MOMP regulation

Table 1 Binding and inhibition between individual members of the Bcl-2 family

Bcl-2	Full name of the protein	Binds to and inhibits	Ref.
protein
Antiapoptotic
Members:
Mcl-1	Myeloid cell leukemia sequence-1	Noxa, Bim, Puma, Bax, Bak	[8, 31]
Bcl-2	B-cell lymphoma 2	Bad, Bim, Puma, Bmf, Bax	[8, 31]
A1	Bcl-2 related protein	Noxa, Bim, Puma, tBid, Hrk, Bik, Bax, Bak	[8, 31]
Bcl-xL	Bcl-2-like	Bad, Bim, Puma, tBid, Hrk, Bmf, Bik, Bak, Bax	[8, 31]
Bcl-w	Bcl-2-like-2	Bad, Bim, Puma, tBid, Hrk, Bmf, Bik, Bax	[8, 31]
Bcl-B	Bcl-2-like-10	Bax	[44]
BH3-only
Members:
Noxa	Phorbol-12-myristate-13-acetate-induced	Mcl-1, A1	[8, 31, 39]
	protein 1
Bad	Bcl-2 antagonist of cell death	Bcl-xL, Bcl-w, Bcl-2	[8, 31, 39]
Bim	Bcl-2like-11	Bcl-xL, Bcl-w, Bcl-2, Mcl-1, A1	[8][31, 39]
Puma	Bcl-2-binding component-3	Bcl-xL, Bcl-w, Bcl-2, Mcl-1, A1	[8, 31, 39]
tBid	truncated BH3-interacting	Bcl-xL, Bcl-w, A1	[31, 39]
	domain death agonist
Hrk	Harakiri	Bcl-xL, Bcl-w, A1	[31]
Bmf	Bcl-2-modifying factor	Bcl-xL, Bcl-w, Bcl-2	[31, 39]
Bik	Bcl-2-interacting killer	Bcl-xL, Bcl-w, A1	[31]
Effectors:
Bak	Bcl-2-antagonist/killer-1	Bcl-xL, Mcl-1, A1	[8, 39]
Bax	Bcl-2-associated X protein	Bcl-xL, Bcl-w, Bcl-2, Bcl-B, Mcl-1, A1	[8, 39]

ISSN: 1742-4682