Figure 4

Schematic illustration of the different possible relations between the viral set point and the failure threshold. In Figure A and B the failure threshold is above the set point. In Figure A a strong resonant case generate a peak in viral load reaching the failure threshold. In Figure B the viral rebound do not reach the failure threshold. Figure C and D show a scenario where the failure threshold is below the set point. In this case the exponential viral rebound, crossing the failure threshold, determines the time of drug failure.