Binding of compounds #1–4 with the iGluA2-LBD dimer. Two molecules of each compound independently bind at the dimer interface are shown in (A), (C), (E) and (G) for the compounds #1, #2, #3, and #4, respectively. The close-view of the corresponding compounds to show protein-ligand interactions are shown in (B), (D), (F) and (H), respectively. For compound #1, the five subsites which are contributing protein-ligand interactions are shown in circles. The ligands and interacting residues are shown in sticks. The oxygen and nitrogen atoms are colored in red and blue, respectively.