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Table 3 Paclitaxel kinetic elimination Michaelis-Menten parameters (converted* from Vaclavikova et al., their Table 4 )

From: A physiologically-based flow network model for hepatic drug elimination I: regular lattice lobule model

Parameter

Characteristic (SI) unit

STARS unit

Maximum rate vmax

0.06 μM/min

1.08 × 10-9 molefrac/min

Half saturation constant Km

10.0 μM

1.8 × 10-7molfrac

Linear rate vmax/Km

6.0 × 10-3 min-1

6.0 × 10-3 min-1

  1. *Their Table 4 quotes vmax = 61 picomol/mg_protein/min. Using their microsomal protein concentration of 1 mg/ml, these numbers convert to vmax = 0.06 μM/min.
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Theoretical Biology and Medical Modelling

ISSN: 1742-4682