Skip to main content
Figure 3 | Theoretical Biology and Medical Modelling

Figure 3

From: Rate-dependent Ca2+ signalling underlying the force-frequency response in rat ventricular myocytes: a coupled electromechanical modeling study

Figure 3

I ryr . Frequency-dependent characteristics of the SR C a2+ release channel I ryr . Voltage clamp protocol used is a 50 ms step pulse to 10 mV from a holding potential of -40 mV. (A) RyR open probability vs [ C a2+] ryr for increasing frequency of stimulation (0.5 Hz to 10.0 Hz). The inset shows the frequency-dependent modulation of peak RyR open probability. (B) Frequency dependence of average charge transported by NCX and average [ N a+] myo in the myoplasm. (C) Rate dependence of pre-release maximum and post-release minimum SR C a2+ level. (D) Traces for RyR release for the corresponding frequencies of stimulation in panel A. (E) Dependence of average level of activated-CaMKII and peak I ryr current on frequency of stimulation. (F) Frequency-dependent changes in average I ryr activation and inactivation rates. The legend for traces in panel A is shared by panel D.

Back to article page