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Table 2 Result from comparison of ATP binding site of MK2, MK3 and MK5

From: Homology modeling and ligand docking of Mitogen-activated protein kinase-activated protein kinase 5 (MK5)

MK5 model

MK2_2OZA (fastafile)

MK2_3M2W (fastafile)

MK3_3FHR (fastafile)

Q26

Q68

Q68

Q48

L28

L70

L70

L50

G29

G71

G71

G51

A30

L72

L72

L52

G31

G73

G73

G53

I32

I74

I74

V54

V36

V78

V78

V58

R47

K89

K89

K69

A49

A91

A91

A71

K51* [8, 9]

K93

K93

K73

E62*

E104

E104

E84

V76

V118

V118

V98

M102**

M138

M138

M118

E103

E139

E139

E119

M104

C140

C140

C120

M105

L141

L141

M121

E106

D142

D142

E122

G107

G143

G143

G123

G108

G144

G144

G124

E152

E190

E190

E170

N153

N191

N191

N171

L155

L193

L193

L172

C168

T206

T206

T186

D169*

D207

D207

D187

  1. * Amino acid important for binding of ATP [58].
  2. ** Gate keeper residue.