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Figure 5 | Theoretical Biology and Medical Modelling

Figure 5

From: Modeling of the hypothalamic-pituitary-adrenal axis-mediated interaction between the serotonin regulation pathway and the stress response using a Boolean approximation: a novel study of depression

Figure 5

The effects of knocking out key nodes in the model. The importance of individual nodes was determined based on the mean Hamming distance calculated from 100 discrete runs following node knockout in the model. The nodes corresponding to CREB, BDNF and TRkB had the greatest negative effect on network stability when knocked out, while those related to 5-HT synthesis had the next greatest negative effect.

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