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Figure 10 | Theoretical Biology and Medical Modelling

Figure 10

From: A patient-specific therapeutic approach for tumour cell population extinction and drug toxicity reduction using control systems-based dose-profile design

Figure 10

Clinical implementation of tumour elimination procedure, using MRI-based tumour-load monitoring method at weekly time intervals. The multimodal therapy starts from point A and its effect on the malignant tissue is monitored by estimating the tumour load (correlate of tumour variable T) using MRI amide proton-transfer imaging, done at time intervals of τ. The blood levels of the therapeutic agents and of its cell populations (circulating lymphocytes, natural killer cells, cytotoxic T-cells etc.) are also measured then. These data are used to give corrective feedback to the therapy system in case there is incongruity between the actual trajectory and the mathematically calculated trajectory desired. Data sampling at τ and any uncertainty or instability of the biological parameters, are taken care by Kalman’s filtering and neuroadaptive control which actuates the infusion pump of the therapeutic inputs to the patient.

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