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Table 3 Description of therapy system terms

From: A patient-specific therapeutic approach for tumour cell population extinction and drug toxicity reduction using control systems-based dose-profile design

Terms

Description

Reference formulation

U M

Therapeutic efficiency factor of Chemotherapy

U M  = {1 − exp(−M)}  [Eq. (10)]

U L

Therapeutic efficiency factor of Cytotoxic T-lymphocytes

U L  = d Ll/(s Tl + Ll) [Eq. (10)]

U I

Therapeutic efficiency factor of Interleukin-2

U I  = p I LI/(g I  + I) [Eq. (27)]

b T

Total tumour cell lysis effect from the two cytotoxic agents, Chemotherapy (temozolomide) and Cytotoxic T-cells

b T  = U M gT 1 + U L gT 2 [Eq. (12)]

b L

Total cytotoxic T-cell activation effect from the two Immuno-modulating agents, Interleukin and Tumour-infiltrating lymphocyte

b L  = U I  + v L [Eq. (29)]