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Figure 4 | Theoretical Biology and Medical Modelling

Figure 4

From: In-silico models of stem cell and developmental systems

Figure 4

Three distinct population dynamics under symmetric and asymmetric proliferation decision at the larva and adult stage. A. Simulation under symmetric proliferation decision in which each division gives rise to an identical daughter proliferation and solely depends on receptor activity. The simulation displays a sustainable proliferative zone at the entire simulation time (tested in > = 30 simulations over time period of 10 min). B. Simulation under symmetric proliferation decision at larvae stages (simulation time < 1:30 min) and asymmetric proliferation decision in which the daughter cell immediately differentiates at the adult stage (simulation time > = 1:30 min). The simulation develops normally at the larvae stages and gradually lost the proliferative zone at the adult stage. C. Simulation under asymmetric proliferation decision at the larval stage. The simulation displays an aberrant development in which the cell population is lost early at the larvae stages and cannot maintain normal cell population. Under these conditions the simulation lasts 1:30 min in total (i.e., all cells were vanished from the gonad structure).

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