Comparison of the in-silico model and experimental data of the neuronal migration process. A. Four Snapshots of the neuronal migration simulation vs. histology of the embryonic mouse cortex. Radial progenitor glial cells (pink) proliferate asymmetrically giving rise to neuroblasts (red). Neuroblasts adopt a multipolar migration and move randomly stage (green). Multipolar neurons enter bipolar stage (yellow) and re-associate with the fiber, and accumulate at the pile surface. B. Lis1 mutants: (left) In-silico migration in Lis1-defective simulations vs. (right) histology of the cortex in Lis1 RNAi mutant mouse (reproduced with permission from ). C. In-silico migration under reduced DCX expression (left) vs. histology of the cortex in DCX RNAi mutant rats (right) (reproduced with permission from ).