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Figure 6 | Theoretical Biology and Medical Modelling

Figure 6

From: In-silico models of stem cell and developmental systems

Figure 6

Emergent oscillatory association-disassociation at the single-neuron level over time (in arbitrary simulation units) (reproduced from [[46]] ). This oscillatory behavior is possibly emerges by a conflict in the instructions coded in the genetic regulatory network. Cells response to an instruction to follow the glial fiber in response to factors in their close environment and at the same time to intrinsic signals that direct them to migrate randomly. Each cell interprets the signal differently leading to different periods and frequencies. This phenomena in four representative neurons is shown: Immediate differentiation (A), short delay (B), long delay (C) and oscillatory association over the entire simulated period (D).

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