Figure 1

Interictal discharges in experiments and in the model, and input signals from DG. (A) LFPs in CA3 region recorded by MEA in a hippocampal slice. Interictal discharges occurred with more than 10 minutes’ delays after Mg²⁺-free-ACSF perfusion. (B) Simulated input signals from the DG which followed a Poisson process (λ = 1). (C) Somatic membrane potentials of one pyramidal cell under different Mg²⁺ concentrations in the model without the input from the EC. Interictal discharges occurred when [Mg²⁺] was 0 mM. [Mg²⁺]: extracellular Mg²⁺ concentration.