Figure 2
From: The role of the entorhinal cortex in epileptiform activities of the hippocampus
Interictal (asterisks) and ictal (continuous lines) discharges in experiments and the model, and input signals. (A) LFPs in the CA3 region recorded by MEA in a combined EC-hippocampal slice. Interictal discharges occurred regularly before an ictal discharge. (B) Simulated input signals from the DG or EC, which were alternate interictal and ictal discharges. (C) Somatic membrane potentials of one pyramidal cell in the model with the input from the EC. When input signals from the DG and EC were alternate interictal and ictal discharges as shown in (B), pyramidal cells in the model produced interictal and ictal discharges. (D) Somatic membrane potentials of one pyramidal cell in the model with the input from the EC. When the input signals from the DG followed a Poisson process as shown in Figure 1B and the input signals from the EC were alternate interictal and ictal discharges as shown in (B), pyramidal cells in the model produced interictal and ictal discharges.