Figure 3
From: The role of the entorhinal cortex in epileptiform activities of the hippocampus
Effects of VPA on interictal activities in experiments and simulations. (A) Interictal discharges before and during 3 mM VPA application in one hippocampal slice, which represents the recording of one electrode in the CA3 region. (B) The somatic membrane potentials of one pyramidal cell in the model without the EC input. The input signals from the DG followed a Poisson process as shown in Figure 1B. When the GABA-ergic connection strength was enhanced and the NMDA-ergic connection strength was reduced, the frequency of interictal discharges decreased.