Figure 4

Effects of VPA on interictal (asterisks) and ictal (continuous lines) activities in experiments and simulations. (A) Epileptiform discharges before and during 3 mM VPA application in a combined EC-hippocampal slice, which represents the recordings of one electrode in the CA3 region. (B) The somatic membrane potentials of a pyramidal cell in the model with the input from the EC. When the GABA-ergic connection strength was enhanced and the NMDA-ergic connection strength was reduced, and the input signals from the EC and DG were interictal discharges with a lower frequency compared to interictal discharges added previously as shown in Figure 2B, ictal discharges disappeared and interictal discharges still existed. (C) The somatic membrane potentials of a pyramidal cell in the model with the input from the EC. When the GABA-ergic connection strength was enhanced and the NMDA-ergic connection strength was reduced, and the input signals from the DG followed a Poisson process as shown in Figure 1B, and the input signals from the EC were alternate interictal and ictal discharges as shown in Figure 2B, ictal and interictal discharges still existed.