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Figure 2 | Theoretical Biology and Medical Modelling

Figure 2

From: Investigation of the essential role of platelet-tumor cell interactions in metastasis progression using an agent-based model

Figure 2

Mechanisms of activation incorporated into the platelet agents of the ABMEM. Extracellular Thrombin (T) binds to Protease-activated receptor (PAR1) and Protease-activated receptor 4 (PAR4) on the platelet agent, inducing the thromboxane (TXA) pathway in a calcium dependent manner to cause the platelet to activate Integrin GpIIb/IIIa. PAR4 also activates intracellular adenosine diphosphate (ADP, A) production. Intracellular ADP induces platelet P-selectin expression. ADP is also released into the extracellular environment and acts in an autocrine and paracrine fashion by binding to Purinergic receptor P2Y (P2Y12) on the platelet, contributing to calcium-mediated expression of the Integrin GpIIb/IIIa.

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Theoretical Biology and Medical Modelling

ISSN: 1742-4682