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Figure 3 | Theoretical Biology and Medical Modelling

Figure 3

From: Investigation of the essential role of platelet-tumor cell interactions in metastasis progression using an agent-based model

Figure 3

Mechanisms of activation incorporated into the neutrophil agents of the ABMEM. Endothelial cells, Platelets and Tumor cells bind to activated Macrophage Antigen 1 (Mac-1). Interleukin 8 (IL-8) released by endothelial cells induces further Mac-1 activation. Thrombin (T) released by Platelets or Tumor cells, and activation of Mac-1 induces reactive oxygen species (ROS) production through a calcium dependent manner, which in turn induces further Mac-1 activation. ROS are also released into the extra-cellular environment to interact with other agents. Nitric oxide released by endothelial cells inhibits ROS production in neutrophils. IL-8: Interleukin-8. ROS – reactive oxygen species. NO – nitric oxide.

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Theoretical Biology and Medical Modelling

ISSN: 1742-4682