Table 1 Key Molecular Pathways Represented in the ABMEM
Protein | Function in ABM |
|---|---|
Integrin αV/β3 | Expressed by tumor cells, binds activated platelet GpIIB/IIIa and activated PMN Mac-1 (αM/β2) |
Mac-1 and LFA-1 | Expressed by PMNs, binds platelet GpIbα and tumor cell Integrin αV/β3 |
N-cadherin | Expressed by PMNs, initiates rolling on endothelial cells. |
L-selectin | Expressed by PMNs, initiates rolling on endothelial cells. |
GpIα | Expressed by platelets, binds PMN αM/β2, activated by GpIIb/IIIa |
GpIIb/IIIa | Expressed by platelets, binds endothelial cells and tumor cells. |
P-selectin | Expressed by platelets, initiates binding to tumor cells, PMNs and endothelial cells. |
Thrombin | Generated by platelets, PMNs and tumor cells, diffuses through world and activates platelets, PMNs and endothelial cells. |
Thromboxane (TXA) | Generated by activated platelets, activates GpIIb/IIIa |
Adenosine Diphosphate (ADP) | Generated by platelets, diffuses and activates GpIIb/IIIa and P-selectin |
Interleukin-8 (IL-8) | Generated by tumor cells, activated PMNs and activated endothelial cells, diffuses through world and activates other cells. |
Nitric Oxide (NO) | Generated by endothelial cells, inhibits PMN ROS production and inhibits endothelial cell activation. |