Figure 10

Hybrid model simulations after chemotherapy, Filgrastim or EPO. We present results of different breast cancer therapies. First row: four cycles of the drug combination epirubicine + cyclophosphamide followed by four cycles of paclitaxel with cycle duration of 21 days without G-CSF, second row: three single drug cycles of epirubicine, paclitaxel, cyclophosphamide applied consecutively with cycle duration of 14 days with Filgrastim on cycle days 3–10, third row: The same therapy as described in second row but with additional EPO Alfa. We show HB and WBC values of simulation (black line), medians (circle), 25th and 75th percentiles (grey dashed line) of patients data. While raw data are available for the first two scenarios, data of the third scenario are taken from [51].