Figure 8

Model simulations of different CHOP chemotherapies with or without Filgrastim support. First row: Six cycles of CHOP with cycle duration of 21 days without Filgrastim, second row: Six cycles of CHOP with cycle duration of 14 days with Filgrastim at day 4–13 at each therapy cycle, third row: Eight cycles of CHOP with cycle duration of 14 days with Filgrastim at day 6–12 at each therapy cycle. We present time series of HB and WBC simulated with our combined model (black solid line) and compare it with corresponding simulation results of the single lineage models (grey solid line). We also compare model results with our clinical data (median: circles, first and third quartile: grey dashed line) taken from the trials published in [45, 63].