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Table 1 Distributions of patients regarding breast tumor type, ER and PgR expression, HER2 overexpression and age (younger than 55, or older than 54)

From: A model of immunohistochemical differences between invasive breast cancers and DCIS lesions tested on a consecutive case series of 1248 patients

  Luminal A and B1 Luminal B2 Total Age Luminal A and B1 Luminal B2 Total
Distribution of breast cancer patients with positive receptors according to HER2 and age
ER+PgR+ 666 172 838 <55 218 69 287
ER+PgR 66 38 104 >54 525 141 666
ERPgR+ 11 0 11 Total 743 210 953
Total 743 210 953
Χ2 (p) 13.70 (0.0002) Χ2(p) 2.34 (0.1260)
Distribution of ductal breast cancer patients according to their steroid receptor phenotype and Ki-67 value
ER+ tumors without HER2 Luminal A (Ki-67 < =14%) Luminal B1 (Ki-67 > 14%) Total Luminal B2 Ki-67 < =14% Ki-67 > 14% Total
ER+PgR+ 365 301 666 ER+PgR+ 49 123 172
ER+PgR 26 40 66 ER+PgR 9 29 38
ERPgR+ 6 5 11 ERPgR+ 0 0 0
Total 397 346 743 Total 58 152 210
Χ2(p) 5.73 (0.0167) Χ2 (p) 0.36 (0.5489)
Distribution of ductal breast cancer patients according to their age and other features
Age of Luminal A patients ER+PgR+ ER+PgR ERPgR+ Age of HER2 patients Ki-67 < =14% Ki-67 > 14% Total
<55 99 5 4 <55 3 38 41
>54 266 21 2 >54 16 78 94
Total 365 26 6 Total 19 116 135
Χ2(p) 0.77 (0.3789)   Χ2 (p) 2.22 (0.1360)  
Age of Luminal B1 patients ER+PgR+ ER+PgR ERPgR+ Age of triple-negative patients Ki-67 < =14% Ki-67 > 14% Total
<55 103 6 1 <55 7 68 75
>54 198 34 4 >54 14 71 85
Total 301 40 5 Total 21 139 160
Χ2(p) 6.00 (0.0143)   Χ2 (p) 1.78 (0.1822)  
Age of Luminal B2 patients ER+PgR+ ER+PgR ERPgR+ Age of patients triple-negative HER2 Total
<55 65 4 0 <55 75 41 116
>54 107 34 0 >54 85 94 179
Total 172 38 0 Total 160 135 295
Χ2(p) 10.49 (0.0012)   Χ2 (p) 8.36 (0.0038)  
  1. The ER+PgR- phenotype was more common in Luminal B2 in comparison to the pooled Luminal A and B1, in Luminal B1. In Luminal B1 and in B2 ER+PgR- tumors were more common in patients older than 54. HER2-overexpressed patients are often older than 54.