Table 2 Results of the ductal cancer progression model from ref. 1 , applied to here presented patients
Ductal breast cancer (DC) types | Ductal breast cancer types | Total | |||||
|---|---|---|---|---|---|---|---|
Luminal A | Luminal B1 | Luminal B2 | HER2+ | Triple-negative | |||
DCIS | A | 34 | 6 | 12 | 10 | 6 | 68 |
IDC | B | 363 | 340 | 198 | 125 | 154 | 1180 |
Number of all DC (A + B) | C | 397 | 346 | 210 | 135 | 160 | 1248 |
% of cancer types in all DC | 31.81% | 27.72% | 16.83% | 10.82% | 12.82% | 100.00% | |
Probability of progression at the time of diagnosis (B/C) | p | 91.44% | 98.27% | 94.29% | 92.59% | 96.25% | 94.55% |
Number of progression t1/2 spent till the time of diagnosis log(1-p)/log(1/2) | 3.55 | 5.85 | 4.13 | 3.75 | 4.74 | 4.20 | |
Relative rate of progression from DCIS to IDC | 84.46% | 139.35% | 98.36% | 89.45% | 112.84% | 100.00% | |
Pooled reported DCIS and IDC data from ref. 1 | Type | Luminal A | Luminal B | HER2+ | Triple-negative | Total | |
DCIS | 153 | 53 | 96 | 26 | 328 | ||
IDC | 124 | 68 | 31 | 109 | 332 | ||
Total | 277 | 121 | 127 | 135 | 660 | ||
Simulated population of all ductal breast cancer patients with 5% DCIS | 2480.61 | 1329.43 | 677.90 | 2072.05 | 6560 | ||
% of cancer types in simulated population | 37.81% | 20.27% | 10.33% | 31.59% | 100.00% | ||
Probability of progression at the time of diagnosis | 93.83% | 96.01% | 85.84% | 98.75% | 95.00% | ||
Number of progression t1/2 spent till the time of diagnosis | 4.02 | 4.65 | 2.82 | 6.32 | 4.32 | ||