|
Binary features
|
DCIS
|
IDC
|
Relative rate
|
Rate difference (positive–negative)
|
|---|
|
ER
|
Negative
|
16
|
290
|
1.0142
|
−0.0186
|
|
Positive
|
52
|
890
|
0.9955
|
|
Total
|
68
|
1180
|
1.0000
| |
|
PgR
|
Negative
|
29
|
370
|
0.9010
|
0.1577
|
|
Positive
|
39
|
810
|
1.0587
|
|
Total
|
68
|
1180
|
1.0000
| |
|
HER2
|
Negative
|
46
|
857
|
1.0231
|
−0.0772
|
|
Positive
|
22
|
323
|
0.9459
|
|
Total
|
68
|
1180
|
1.0000
| |
|
Ki-67
|
<=14%
|
43
|
451
|
0.8390
|
0.3317
|
|
>14
|
25
|
729
|
1.1707
|
|
Total
|
68
|
1180
|
1.0000
| |
|
Ductal breast cancer types including Luminal B1 and proposed other Ki-67 subtypes
|
Luminal A
|
34
|
363
|
0.8446
|
0.5489
|
|
Luminal B1
|
6
|
340
|
1.3936
|
|
Luminal B2
|
<=14%
|
4
|
54
|
0.9190
|
0.0929
|
|
>14%
|
8
|
144
|
1.0119
|
|
HER2
|
<=14%
|
4
|
15
|
0.5355
|
0.4824
|
|
>14%
|
6
|
110
|
1.0179
|
|
Triple-negative
|
<=14%
|
1
|
20
|
1.0463
|
0.0964
|
|
>14%
|
5
|
134
|
1.1427
|
|
Total
|
68
|
1180
|
1.0000
| |
- Because Luminal B1 cancers differ from Luminal A cancers only by Ki-67 values, the same threshold of the 14% Ki-67 value was applied to Luminal B2, HER2-overexpressed and triple-negative cancers. Luminal B1 phenotype was 39% faster than average in progression. The rare combination of low Ki-67 in HER2-overexpressed cancers (14% of HER2 cancers) showed very slow rate of transition to IDC (only 53.55% of the average rate).
