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Table 3 Relative tissue invasion rates according to the Ki-67 value

From: A model of immunohistochemical differences between invasive breast cancers and DCIS lesions tested on a consecutive case series of 1248 patients

Binary features DCIS IDC Relative rate Rate difference (positive–negative)
ER Negative 16 290 1.0142 −0.0186
Positive 52 890 0.9955
Total 68 1180 1.0000  
PgR Negative 29 370 0.9010 0.1577
Positive 39 810 1.0587
Total 68 1180 1.0000  
HER2 Negative 46 857 1.0231 −0.0772
Positive 22 323 0.9459
Total 68 1180 1.0000  
Ki-67 <=14% 43 451 0.8390 0.3317
>14 25 729 1.1707
Total 68 1180 1.0000  
Ductal breast cancer types including Luminal B1 and proposed other Ki-67 subtypes Luminal A 34 363 0.8446 0.5489
Luminal B1 6 340 1.3936
Luminal B2 <=14% 4 54 0.9190 0.0929
>14% 8 144 1.0119
HER2 <=14% 4 15 0.5355 0.4824
>14% 6 110 1.0179
Triple-negative <=14% 1 20 1.0463 0.0964
>14% 5 134 1.1427
Total 68 1180 1.0000  
  1. Because Luminal B1 cancers differ from Luminal A cancers only by Ki-67 values, the same threshold of the 14% Ki-67 value was applied to Luminal B2, HER2-overexpressed and triple-negative cancers. Luminal B1 phenotype was 39% faster than average in progression. The rare combination of low Ki-67 in HER2-overexpressed cancers (14% of HER2 cancers) showed very slow rate of transition to IDC (only 53.55% of the average rate).