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Table 4 Relative tumor invasion rates according to the expression of hormonal receptors

From: A model of immunohistochemical differences between invasive breast cancers and DCIS lesions tested on a consecutive case series of 1248 patients

       Combined features DCIS IDC Relative rate Rate difference (ER+PgRER+PgR+)
Ductal breast cancer phenotypes of steroid receptor expression ER+PgR+ 39 799 1.0542 −0.3396
ER+PgR 13 91 0.7146
ERPgR+ 0 11 n/a  
ERPgR 16 279 1.0016
Total 68 1180 1.0000
Luminal A cancers: steroid receptor phenotype ER+PgR+ 28 337 0.8824 −0.3785
ER+PgR 6 20 0.5039
ERPgR+ 0 6 n/a  
Total 34 363 0.8446
Luminal B1 cancers: steroid receptor phenotype ER+PgR+ 4 297 1.4849 −0.4554
ER+PgR 2 38 1.0295
ERPgR+ 0 5 n/a  
Total 6 340 1.3934
Luminal B2 cancers: steroid receptor phenotype <=14% ER+PgR+ 4 45 0.8606 n/a
ER+PgR 0 9 n/a
>14% ER+PgR+ 3 120 1.2756 −0.6718
ER+PgR 5 24 0.6038
Total 12 198 0.9832  
  1. In all three tumor types with positive steroid receptors the ER+PgR- phenotype showed slower transition rates to the IDC phase than the functional ER+PgR+ phenotype ( 38% for Luminal A, 46% for Luminal B1 and 67% for Luminal B2 with Ki67 > 14%).