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Table 4 Relative tumor invasion rates according to the expression of hormonal receptors

From: A model of immunohistochemical differences between invasive breast cancers and DCIS lesions tested on a consecutive case series of 1248 patients

       Combined features

DCIS

IDC

Relative rate

Rate difference (ER+PgRER+PgR+)

Ductal breast cancer phenotypes of steroid receptor expression

ER+PgR+

39

799

1.0542

−0.3396

ER+PgR

13

91

0.7146

ERPgR+

0

11

n/a

 

ERPgR

16

279

1.0016

Total

68

1180

1.0000

Luminal A cancers: steroid receptor phenotype

ER+PgR+

28

337

0.8824

−0.3785

ER+PgR

6

20

0.5039

ERPgR+

0

6

n/a

 

Total

34

363

0.8446

Luminal B1 cancers: steroid receptor phenotype

ER+PgR+

4

297

1.4849

−0.4554

ER+PgR

2

38

1.0295

ERPgR+

0

5

n/a

 

Total

6

340

1.3934

Luminal B2 cancers: steroid receptor phenotype

<=14%

ER+PgR+

4

45

0.8606

n/a

ER+PgR

0

9

n/a

>14%

ER+PgR+

3

120

1.2756

−0.6718

ER+PgR

5

24

0.6038

Total

12

198

0.9832

 
  1. In all three tumor types with positive steroid receptors the ER+PgR- phenotype showed slower transition rates to the IDC phase than the functional ER+PgR+ phenotype ( 38% for Luminal A, 46% for Luminal B1 and 67% for Luminal B2 with Ki67 > 14%).