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Table 5 Comparison of calculated relative rates of tissue invasion between patients younger than 55 vs. older patients

From: A model of immunohistochemical differences between invasive breast cancers and DCIS lesions tested on a consecutive case series of 1248 patients

Features

Age <55 years

Age >54 years

Rate difference (older-younger)

DCIS

IDC

Relative rate

DCIS

IDC

Relative rate

Luminal A

8

100

0.8944

26

263

0.8277

−0.0667

Luminal B1

2

108

1.3772

4

232

1.4013

0.0241

Luminal B2

4

65

0.9787

8

133

0.9861

0.0074

HER2

4

37

0.7998

6

88

0.9456

0.1458

Triple-negative

2

73

1.2456

4

81

1.0504

−0.1952

Total

18

275

0.9588

44

565

0.903

−0.0558

ER+PgR+

14

253

1.0151

25

546

1.0752

0.0601

ER+PgR

0

15

n/a

13

76

0.6611

n/a

ERPgR

6

110

1.0198

10

169

0.9914

−0.0284

Total

20

378

1.0298

48

791

0.9832

−0.0466

  1. The main difference was found in patients with triple-negative tumors that were in younger patients 24% faster than the expected average, while in older patients it was only 5% above the expected value. In HER2-overexpressed tumors, among older patients, the rate of tumor invasion was a just 5% bellow the expected value, but in younger patients the tissue invasion rate was 20% below the expected values. The ER+ER- phenotype was 33% slower than expected in older patients and incalculably fast in younger patients with no DCIS found among 15 younger patients.