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Table 5 Comparison of calculated relative rates of tissue invasion between patients younger than 55 vs. older patients

From: A model of immunohistochemical differences between invasive breast cancers and DCIS lesions tested on a consecutive case series of 1248 patients

Features Age <55 years Age >54 years Rate difference (older-younger)
DCIS IDC Relative rate DCIS IDC Relative rate
Luminal A 8 100 0.8944 26 263 0.8277 −0.0667
Luminal B1 2 108 1.3772 4 232 1.4013 0.0241
Luminal B2 4 65 0.9787 8 133 0.9861 0.0074
HER2 4 37 0.7998 6 88 0.9456 0.1458
Triple-negative 2 73 1.2456 4 81 1.0504 −0.1952
Total 18 275 0.9588 44 565 0.903 −0.0558
ER+PgR+ 14 253 1.0151 25 546 1.0752 0.0601
ER+PgR 0 15 n/a 13 76 0.6611 n/a
ERPgR 6 110 1.0198 10 169 0.9914 −0.0284
Total 20 378 1.0298 48 791 0.9832 −0.0466
  1. The main difference was found in patients with triple-negative tumors that were in younger patients 24% faster than the expected average, while in older patients it was only 5% above the expected value. In HER2-overexpressed tumors, among older patients, the rate of tumor invasion was a just 5% bellow the expected value, but in younger patients the tissue invasion rate was 20% below the expected values. The ER+ER- phenotype was 33% slower than expected in older patients and incalculably fast in younger patients with no DCIS found among 15 younger patients.