Figure 1
From: Quantitative indices of autophagy activity from minimal models
Schematic representation of the model system and quantitative indices. The model assumes a three-compartment description of the autophagic process: protein/organelle, autophagosome, and autolysosome compartments. Solid and dotted arrows denote the autophagic feedback loops among the compartments and non-autophagic degradation, respectively. The autophagy-related rates, including protein/organelle synthesis R S (C A , C a ), autophagosome formation Rg 1(C A , C a ) and Rg 2(C A , C a ), autolysosome formation R l (C A ), intralysosomal hydrolysis R h (C A ), and non-autophagic degradation Rd 1 and Rd 2 are described in Appendix A. Dashed arrows indicate the quantitative indices f c , ΦS, and ΦI of protein/organelle quality, autophagy selectivity, and autophagy induction, respectively.