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Table 1 Parameters in the model

From: Quantitative indices of autophagy activity from minimal models

Symbol Definition   Unit Value Reference
r g 0 Rate constant for autophagosome formation (normal value) s− 1 * 1.12 × 10− 5 [12], [13], [14]
k g Constant for autophagosome formation (ATP dependency) mM * 4.01 [12], [14]
p g Constant for autophagosome formation (ATP dependency) mM * 3.00 [12], [14]
a g Constant for autophagosome formation (amino acids dependency) mM 4.50  
γ g Constant for autophagosome formation (amino acids dependency) (unitless) * 1.22 [13]
ξ g Constant for autophagosome formation (amino acids dependency) mM− 1 * 7.49 × 10− 2 [13]
r l Rate constant for autolysosome formation s− 1 * 2.47 × 10− 5 [12], [14]
k l Constant for autolysosome formation (ATP dependency) mM * 4.01 [12], [14]
p l Constant for autolysosome formation (ATP dependency) mM * 3.00 [12], [14]
r h Rate constant for intralysosomal hydrolysis s− 1 * 1.39 × 10− 5 [12], [14]
δ h Exponent for intralysosomal hydrolysis (ATP dependency) (unitless) * 7.24 × 10− 1 [12], [14]
k h Constant for intralysosomal hydrolysis (ATP dependency) mM * 2.99 [12], [14]
r s Rate constant for protein/organelle synthesis mM  s− 1 * 1.48 × 10− 5 [34]
k s Constant for protein/organelle synthesis (amino acids dependency) mM * 1.77 × 101 [34]
C A m ATP concentration corresponding to maximal protein/organelle synthesis rate mM 3.00  
  1. Parameters with asterisks (*) are fixed, determined from biological experiments [1214, 34]. Those without asterisks are adjustable, depending on experimental setups.