Parameter (unit) | Number or median (range) | |
---|---|---|
IV | PO | |
Patients | 19 | 20 |
Sex: male/female | 10/9 | 12/8 |
Age at transplantation (year) | 10.5 (1–18) | 11.1 (0.5–18.2) |
Transplantation type: Sibling/Unrelated | 10/9 | 13/7 |
Included PK profiles | 23 | 39 |
Formulation | 23 (IV) | 19 (Susp)/20 (Cap) |
Time post transplantation (month) | 0.13 (0.1–1.7) | 1.28 (0.7–9.1) |
Age at PK profile (year) | 10.4 (1–17.9) | 11.9 (1.2–18.3) |
Weight (kg) | 33 (10–81) | 38 (8–83) |
Cyclosporine dose (mg/kg/day) | 2.5 (1–3.2) | 4.2 (1–8.3) |
Concomitant corticosteroid | 13 | 26† |
Albumin (g/L) | 32 (19–48) | 32 (22–41)‡ |
Creatinine (mmol/L) | 33 (12–358) | 50 (13–117)‡ |
Bilirubin (μmol/L) | 11 (5–64) | 10 (3–596)‡ |
AST (U/L) | 20 (9–42) | 24 (13–125)‡ |
ALT (U/L) | 24 (9–85) | 31 (19–69)‡ |
GGT (U/L) | 35 (8–94) | 32 (9–217)‡ |
AP (U/L) | 87 (1.9–203) | 110 (53–302)‡ |
Hb (g/dL) | 93 (64–143) | 87 (64–122)‡ |
Hct (%) | 25 (18–44) | 26 (19–36)‡ |