Skip to main content

Table 1 Patients’ information summary

From: Bayesian approach for the estimation of cyclosporine area under the curve using limited sampling strategies in pediatric hematopoietic stem cell transplantation

Parameter (unit)

Number or median (range)

 

IV

PO

Patients

19

20

Sex: male/female

10/9

12/8

Age at transplantation (year)

10.5 (1–18)

11.1 (0.5–18.2)

Transplantation type: Sibling/Unrelated

10/9

13/7

Included PK profiles

23

39

Formulation

23 (IV)

19 (Susp)/20 (Cap)

Time post transplantation (month)

0.13 (0.1–1.7)

1.28 (0.7–9.1)

Age at PK profile (year)

10.4 (1–17.9)

11.9 (1.2–18.3)

Weight (kg)

33 (10–81)

38 (8–83)

Cyclosporine dose (mg/kg/day)

2.5 (1–3.2)

4.2 (1–8.3)

Concomitant corticosteroid

13

26

Albumin (g/L)

32 (19–48)

32 (22–41)

Creatinine (mmol/L)

33 (12–358)

50 (13–117)

Bilirubin (μmol/L)

11 (5–64)

10 (3–596)

AST (U/L)

20 (9–42)

24 (13–125)

ALT (U/L)

24 (9–85)

31 (19–69)

GGT (U/L)

35 (8–94)

32 (9–217)

AP (U/L)

87 (1.9–203)

110 (53–302)

Hb (g/dL)

93 (64–143)

87 (64–122)

Hct (%)

25 (18–44)

26 (19–36)

  1. ALT: alanine aminotransferase; AP: alkaline phosphatase; AST: aspartate aminotransferase; Hb: hemoglobin; Hct: hematocrit; IV: intravenous administration; GGT: γ- glutamyltranspeptidase; PK: pharmacokinetic; PO: oral administration; Susp: suspension; Cap: capsule.
  2. Data available for 37 profiles.
  3. Data available for 38 profiles.