Bayesian approach for the estimation of cyclosporine area under the curve using limited sampling strategies in pediatric hematopoietic stem cell transplantation

Sarem, Sarem; Li, Jun; Barriere, Olivier; Litalien, Catherine; Théorêt, Yves; Lapeyraque, Anne-Laure; Nekka, Fahima

doi:10.1186/1742-4682-11-39

Theoretical Biology and Medical Modelling

Table 2 Performance of B-LSS for AUC prediction using selected Pop-PK models

From: Bayesian approach for the estimation of cyclosporine area under the curve using limited sampling strategies in pediatric hematopoietic stem cell transplantation

	*Model 1*	95^thAPE%	Model 2	95^thAPE%	Model 3	95^thAPE%	*Model 4*	95^thAPE%	Model 5	95^thAPE%	*Model 6*	95^thAPE%
OFV	-1900		-1895		-1613		-1790		-1773		-1447
IV	C2, C2.5, C6, C10	10	C2, C3, C6, C8	11	C2, C2.5, C6, C10	23	C2, C2.5, C8, C10	7	C2, C2.5, C8, C10	8	C2, C2.5, C4, C6	15
	C0, C2, C3, C4	18	C0, C2, C3, C4	18	C0, C2, C2.5, C4	27	C0, C2, C3, C4	14	C0, C2, C3, C4	14	C0, C2.5, C3, C4	22
	C0, C2, C2.5, C4	19	C0, C2, C2.5, C4	19	C0, C2, C3, C4	27	C0, C2, C2.5, C3	15	C0, C2, C2.5, C3	15	C0, C2, C2.5, C4	24
	C0, C2, C2.5, C3	19	C0, C2, C2.5, C3	19	C0, C2, C2.5, C3	27	C0, C2, C2.5, C4	16	C0, C2, C2.5, C4	16	C0, C2, C2.5, C3	24
	C2, C2.5, C10	12	C2, C3, C8	13	C2, C2.5, C6	24	C2, C2.5, C8	10	C2, C2.5, C8	10	C2.5, C8, C10	16
	C0, C2, C3	20	C0, C2.5, C3	20	C0, C2, C3	28	C0, C2, C3	16	C0, C2, C3	16	C0, C2.5, C4	20
	C0, C3, C4	20	C0, C2, C3	21	C0, C2, C4	28	C0, C2.5, C3	18	C0, C2.5, C4	19	C0, C2, C4	22
	C0, C2.5, C3	20	C0, C3, C4	21	C0, C2.5, C3	28	C0, C2.5, C4	19	C0, C2.5, C3	19	C0, C2.5, C3	24
	C2.5, C6	17	C2.5, C6	17	C2.5, C6	27	C2.5, C8	15	C2.5, C8	15	C2.5, C8	20
	C0, C3	21	C0, C3	22	C0, C3	31	C0, C2.5	20	C0, C2.5	21	C0, C2.5	23
	C0, C4	23	C0, C4	24	C0, C2.5	32	C0, C3	20	C0, C3	21	C0, C2	27
	C0, C2.5	24	C0, C2.5	25	C0, C4	37	C0, C4	25	C0, C4	24	C0, C3	30
	C6	24	C6	23	C3	33	C4	23	C4	22	C2.5	28
	C0	37	C0	37	C0	45	C0	40	C0	38	C0	51
PO	C1, C3, C4, C12	14	C1, C3, C4, C8	15	C1, C3, C4, C8	16	C1.5, C3, C4, C12	13	C1.5, C3, C4, C12	13	C1.5, C3, C4, C8	14
	C0, C1, C3, C4	27	C0, C1, C3, C4	32	C0, C1, C3, C4	20	C0, C1, C2, C4	23	C0, C1.5, C3, C4	25	C0, C1.5, C2, C4	16
	C0, C1, C2, C4	28	C0, C1, C2, C4	33	C0, C1, C2, C4	22	C0, C1.5, C3, C4	24	C0, C1, C2, C4	25	C0, C1.5, C3, C4	16
	C0, C0.5, C3, C4	32	C0, C0.5, C3, C4	35	C0, C1.5, C2, C4	24	C0, C1, C3, C4	25	C0, C1, C3, C4	26	C0, C1, C3, C4	18
	C1, C3, C4	21	C1, C3, C4	22	C1, C3, C4	20	C2, C4, C12	16	C1, C3, C8	17	C0.5, C3, C4	18
	C0, C1, C4	35	C0, C1, C4	39	C0, C1, C4	30	C0, C1, C4	30	C0, C1, C4	30	C0, C2, C4	24
	C0, C1.5, C4	38	C0, C0.5, C4	41	C0, C1.5, C4	33	C0, C2, C4	30	C0, C2, C4	33	C0, C1, C4	24
	C0, C2, C4	40	C0, C1.5, C4	42	C0, C1, C3	35	C0, C2, C3	35	C0, C1.5, C4	36	C0, C1, C3	28
	C1, C4	27	C1.5, C4	31	C1, C4	29	C1, C4	24	C1, C4	26	C1, C4	25
	C0, C2	61	C0, C2	64	C0, C4	50	C0, C3	45	C0, C3	46	C0, C3	41
	C0, C1	65	C0, C4	68	C0, C3	51	C0, C1	47	C0, C1	49	C0, C4	43
	C0, C4	66	C0, C1	69	C0, C1.5	61	C0, C2	54	C0, C2	55	C0, C2	44
	C3	45	C3	49	C4	41	C3	40	C3	40	C3	33
	C0	99	C0	99	C0	100	C0	86	C0	85	C0	86

Model 1: significant covariates included, combined error model (final model).
Model 2: significant covariates included, proportional error model.
Model 3: significant covariates included, additive error model.
Model 4: no covariates, combined error model (selected structural model): best model for B-LSS application regarding IV profiles.
Model 5: no covariates, proportional error model.
Model 6: no covariates, additive error model: best model for B-LSS application regarding PO profiles.
C_t: concentration at time t in hours post-dose, OFV: objective function value, 95^th APE%: 95^th percentile of the absolute relative errors.

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