Bayesian approach for the estimation of cyclosporine area under the curve using limited sampling strategies in pediatric hematopoietic stem cell transplantation

Table 4 Parameter estimates for the two structural Pop-PK models selected for B-LSS application

		Structural Pop-PK model with combined residual error				Structural Pop-PK model with additive residual error
PK parameters		NONMEM fixed effect parameters		Inter-individual variability%		NONMEM fixed effect parameters		Inter-individual variability%
PK parameters		estimate	RSE%	estimate	RSE%	estimate	RSE%	estimate	RSE%
CL		14.82	7	31	14	14.49	8	32	15
Vc		31.8	9	†		24.91	10	†
Q		13.49	13	80	11	13.14	15	100	14
Vp		104.6	10	-	-	86.15	8	-	-
KA		0.71	16	83	11	0.58	13	75	10
ALAG		0.39	6	-	-	0.39	6	-	-
F		0.61	10	32	24	0.61	11	29	24
θ8		0.86	10	-	-	1.02	15	-	-
Cov (CL, Q)		-	-	44	27	-	-	48	22
Residual error	Prop.	17.5				-
Residual error	Add.	15 ng/mL				100 ng/mL

The selected Pop-PK models are the structural model with combined errors (Model 4 in Table 2) and the one with additive errors (Model 6 in Table 2) for IV and PO CsA, respectively.
^†Inter-individual variability (Vc) = Inter-individual variability (CL) × θ8.
CL: clearance, Vc: apparent volume of distribution of the central compartment, Vp: apparent volume of distribution of the peripheral compartment, Q: inter-compartmental transfer rate, KA absorption rate, ALAG: lag time in oral absorption, F: oral bioavailability, RSE%: relative standard errors.

ISSN: 1742-4682