Skip to main content

Table 1 Predicted therapeutic parameters for preventing OP-induced intoxication

From: Potential new therapeutic modality revealed through agent-based modeling of the neuromuscular junction and acetylcholinesterase inhibition

Inhibitor Highest IARa Target e.p.p. duration ε-inhb
VX 1.43 0.939 s .012
VR 1.67 2.604 s .026
GA 10 0.639 s .086
GB 1.67 0.627 s .046
GD 5 1.704 s .066
GF 3.33 2.604 s .034
DFP 2 0.517 s .094
Paraoxon 1.67 0.567 s .080
  1. aHighest ratio to return e.p.p. shift duration to 75% of inhibited at 1:1 inhibitor:AChE (partial AChE inhibition). ε-on, ε-off, ε-cat = 1; ε-inh = 0.1.
  2. bLowest activation coefficient to e.p.p. duration to 20% of uninhibited at 1:1 GB:AChE (full AChE inhibition) and IAR.