Potential new therapeutic modality revealed through agent-based modeling of the neuromuscular junction and acetylcholinesterase inhibition

Table 1 Predicted therapeutic parameters for preventing OP-induced intoxication

Inhibitor	Highest IAR^a	Target e.p.p. duration	ε-inh^b
VX	1.43	0.939 s	.012
VR	1.67	2.604 s	.026
GA	10	0.639 s	.086
GB	1.67	0.627 s	.046
GD	5	1.704 s	.066
GF	3.33	2.604 s	.034
DFP	2	0.517 s	.094
Paraoxon	1.67	0.567 s	.080

^aHighest ratio to return e.p.p. shift duration to 75% of inhibited at 1:1 inhibitor:AChE (partial AChE inhibition). ε-on, ε-off, ε-cat = 1; ε-inh = 0.1.
^bLowest activation coefficient to e.p.p. duration to 20% of uninhibited at 1:1 GB:AChE (full AChE inhibition) and IAR.

ISSN: 1742-4682