A scenario of school closure during the course of an influenza pandemic. School closure is implemented for 7 days from Day 50. The basic reproduction number is set at 1.4. Panel A. The average number of child-to-child secondary transmissions in the absence of the depletion of susceptibles. There is an abrupt 70% decline in the child-to-child secondary transmissions, while no compensatory contact with adults is assumed at the baseline. B. Age-dependent prevalence (i.e. the age-specific number of infectious individuals) as a function of calendar time.