Table 8 Predicted impact of detected nonsynonymous SNPs on protein function.
nsSNP | Gene | PANTHER subSPEC | SNAP RI | SIFT Score | SIFT MSC | SIFT NSatP | PolyPhen Score | PolyPhen Sensitivity | PolyPhen Specificity | PhD SNP RI |
|---|---|---|---|---|---|---|---|---|---|---|
rs30775581 | Htr5b | -3.716 | 0 | 0.54 | 3.56 | 21 | 0.001 | 0.99 | 0.15 | 2 |
rs30775583 | Htr5b | -4.093 | 4 | 0.33 | 2.99 | 28 | 0.130 | 0.93 | 0.86 | 6 |
rs30776464 | Htr5b | no data available | 1 | 0.59 | 3.17 | 13 | 0.000 | 1.00 | 0.00 | 6 |
rs30776698 | Ccdc93 | -1.127 | 5 | 1.00 | 4.32 | 3 | 0.000 | 1.00 | 0.00 | 7 |
rs51441999 | Cc2d2a | -2.701 | 5 | 0.48 | 3.08 | 24 | 0.006 | 0.97 | 0.75 | 8 |
rs51455675 | Msh3 | -3.086 | 4 | 0.77 | 3.03 | 25 | 0.002 | 0.99 | 0.30 | 4 |
rs48840878 | Msh3 | -3.452 | 2 | 0.31 | 3.03 | 25 | 0.726 | 0.86 | 0.92 | 2 |
rs31954017 | Glant6 | -4.150 | 6 | 1.00 | 3.03 | 56 | 0.000 | 1.00 | 0.00 | 6 |